2022年11月17日 星期四
2022年11月11日 星期五
2022年11月10日 星期四
Hypoxia aggravates cell death and poor fibronectin deposition of the human gingival fibroblasts treated with Alendronate.
Edward Chengchuan KO
Takao, Formosa
MRONJ (Medication-Related OsteoNecrosis of Jaw) became one of the most challenging diseases for maxillofacial surgeons. Yet it has no definite protocol for treatment. Hyperbaric oxygen therapy (HBO) could increase wound healing though it is still controversial. Current studies indicate that bisphosphonates can inhibit fibronectin's formation and hence inhibit fibroblasts' proliferation and migration. This is one of the phenomena of inadequate wound healing with the consequent attack of MRONJ. No literature mentions the in vitro study regarding the influence of different oxygen conditions on the wound healing of the gingival fibroblasts. Our pilot study using the three kinds of bisphosphonates (including alendronate, zoledronate, and Ibandronate) reveals that hypoxia can cause injury on the bisphosphonates-treated gingival fibroblasts. Alendronate-treated gingival fibroblasts are the most sensitive group to the condition of hypoxia.
1. Hypoxia decreases the cell proliferation of the in vitro cultured human gingival fibroblasts (HGnF) under the treatment of bisphosphonates
2. Hypoxia decreases the wound healing of the in vitro gingival fibroblasts (HGnF) treated with the bisphosphonates
3. Hypoxia enhances the expression of HIF-1α in vitro gingival fibroblasts (HGnF) treated with bisphosphonates.
4. Both hypoxia and hyperbaric oxygen decreased the secretion of HIF-1α from BP-treated HGnF cells.
We know that hyperbaric oxygen could enhance the expression of fibronectin and collagen type I, but owing to the influence of bisphosphonates, cell proliferation and wound healing is still unstable even under the condition of hyperbaric oxygen.
Medial Approach to Mandibular Condyle for Intraoral TMJ Gap Arthroplasty by using Piezo and Surgical Guide
Edward Chengchuan KO
Kaban’s protocol via preauricular approach has been the protocol for treating TMJ ankylosis for a long time though all roads lead to Rome.
In 2009, we published a paper titled as “Intraoral approach for arthroplasty for correction of TMJ ankylosis” in the international journal of Oral and Maxillofacial Surgery. This technique is originally innovated by our great master Professor Steve Sheng-Tsung Lai. As in his original design, the periosteum overlying the outer surface of the mandibular ramus is reflected, and the bur was used to create the gap from the outer surface of the ramus. Meticulous retraction for protection is the top priority during the surgical procedure.
Changes happen with the advent of piezo and 3D imaging. I would like to share my limited experience here regarding the medial approach to mandibular condyle for intraoral TMJ Gap Arthroplasty by using Piezo and surgical guide. The long shank piezo blade (ACTEON® ) and the precise surgical guide really shift the paradigm and shorten the period of surgery.
Reference
Int J Oral Maxillofac Surg. 2009 Dec;38(12):1256-62.doi: 10.1016/j.ijom.2009.07.016.Epub 2009 Sep 3.
2022年11月9日 星期三
Edward Chengchuan KO
Education
l PhD, Surgical Science, The University of Tokyo, Japan
l MS, Oral and Maxillofacial Surgery, Kaohsiung Medical University, Taiwan
l DDS, School of Dentistry, Kaohsiung Medical College, Taiwan
Current Position
l Chief, Liberty Lab of Tissue Engineering Takao, Kaohsiung, Taiwan
l Associate Professor, Division of Oral and Maxillofacial Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan
l Associate Professor, Institute of Precision Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan
l Researcher, Dept. of FUJISOFT Cartilage and Bone Regeneration, Tissue Engineering, The U of Tokyo
l Attending surgeon, Dept. of Oral and Maxillofacial Surgery, Hospital of Kaohsiung Medical University, Kaohsiung, Taiwan
Diploma
l Certificated Maxillofacial Surgeon of Taiwan
l Certificated Facial plastic and reconstructive surgeon of Taiwan
History in Profession
l July 1995, Admitted to Army Medical School for military training
l Oct 1995- June, 1997 Medical Officer ranked as Second Lieutenant at Infirmary of Infantry Division 146, the 8th Corps of Taiwanese Army
l Finished military service in Army
l July 1, 1997, Resident, Dept of Oral and Maxillofacial Surgery, Kaohsiung Medical University Hospital
l 2000-2001 Chief Resident, Division of Oral and Maxillofacial Surgery, Kaohsiung Medical University Hospital
l 2001-2002 Fellow and head, Div. of Oral and Maxillofacial Surgery, Kaohsiung Chang Kung Memorial Hospital
l Aug 1, 2002- Feb 28, 2006Attending Surgeon, Dept of Oral and Maxillofacial Surgery, Taichung China Medical University Hospital
l Sep 1, 2008 - Mar 31, 2010 Research Assistant of Global COE program
l Arp 1, 2010 - now Researcher, Fujisoft Dept (Lab) of Cartilage and Bone Regeneration, The University of Tokyo, Japan
Overseas clinical visit
l The U of Tokyo Hospital, Japan (2006-2010)
l Karl-Frazen Universität, Graz and Medizinische Universität Wien, Austria (2003)
l St Mary’s Hospital of Catholic University and Jelim Plastic Surgery Clinic, Seoul, Korea (2010, 2011, 2014)
- China Medical University in Shenyang, China, and the 9th People’s Hospital in Shanghai, China (2011)
2022年11月5日 星期六
Jaden Chun-yin LEE
DDS, National Yang-Ming University
Specialist, Oral and Maxillofacial Surgery in Taichung veterans general hospital
Specialist, Taiwanese Association of Oral and Maxillofacial surgeons
Specialist, Taiwan Academy of Osseointegration
Member, Academy of Osseointegration, USA
Specialist and director, Imperial dental care, Hsinchu City
李俊瑩醫師
學歷：
國立陽明大學牙醫學士
經歷：
台中榮民總醫院口腔醫學部 住院醫師，總醫師
台中榮總口腔顎面外科專科醫師
中華民國口腔顎面外科專科醫師
台灣植牙醫學會專科醫師
台灣植牙聯盟醫學會專科醫師
紐約哥倫比亞大學植牙教育專班
美國骨整合學會會員
現任：
新竹品御牙醫診所負責醫師
All-on-4及導航植牙訓練課程指導講師