2022年11月17日 星期四
2022年11月11日 星期五
2022年11月10日 星期四
Hypoxia aggravates cell death and poor fibronectin deposition of the human gingival fibroblasts treated with Alendronate.
Edward Chengchuan KO
Takao, Formosa
MRONJ (Medication-Related OsteoNecrosis of Jaw) became one of the most challenging diseases for maxillofacial surgeons. Yet it has no definite protocol for treatment. Hyperbaric oxygen therapy (HBO) could increase wound healing though it is still controversial. Current studies indicate that bisphosphonates can inhibit fibronectin's formation and hence inhibit fibroblasts' proliferation and migration. This is one of the phenomena of inadequate wound healing with the consequent attack of MRONJ. No literature mentions the in vitro study regarding the influence of different oxygen conditions on the wound healing of the gingival fibroblasts. Our pilot study using the three kinds of bisphosphonates (including alendronate, zoledronate, and Ibandronate) reveals that hypoxia can cause injury on the bisphosphonates-treated gingival fibroblasts. Alendronate-treated gingival fibroblasts are the most sensitive group to the condition of hypoxia.
1. Hypoxia decreases the cell proliferation of the in vitro cultured human gingival fibroblasts (HGnF) under the treatment of bisphosphonates
2. Hypoxia decreases the wound healing of the in vitro gingival fibroblasts (HGnF) treated with the bisphosphonates
3. Hypoxia enhances the expression of HIF-1α in vitro gingival fibroblasts (HGnF) treated with bisphosphonates.
4. Both hypoxia and hyperbaric oxygen decreased the secretion of HIF-1α from BP-treated HGnF cells.
We know that hyperbaric oxygen could enhance the expression of fibronectin and collagen type I, but owing to the influence of bisphosphonates, cell proliferation and wound healing is still unstable even under the condition of hyperbaric oxygen.
Medial Approach to Mandibular Condyle for Intraoral TMJ Gap Arthroplasty by using Piezo and Surgical Guide
Edward Chengchuan KO
Kaban’s protocol via preauricular approach has been the protocol for treating TMJ ankylosis for a long time though all roads lead to Rome.
In 2009, we published a paper titled as “Intraoral approach for arthroplasty for correction of TMJ ankylosis” in the international journal of Oral and Maxillofacial Surgery. This technique is originally innovated by our great master Professor Steve Sheng-Tsung Lai. As in his original design, the periosteum overlying the outer surface of the mandibular ramus is reflected, and the bur was used to create the gap from the outer surface of the ramus. Meticulous retraction for protection is the top priority during the surgical procedure.
Changes happen with the advent of piezo and 3D imaging. I would like to share my limited experience here regarding the medial approach to mandibular condyle for intraoral TMJ Gap Arthroplasty by using Piezo and surgical guide. The long shank piezo blade (ACTEON® ) and the precise surgical guide really shift the paradigm and shorten the period of surgery.
Reference
Int J Oral Maxillofac Surg. 2009 Dec;38(12):1256-62.doi: 10.1016/j.ijom.2009.07.016.Epub 2009 Sep 3.
2022年11月9日 星期三
Edward Chengchuan KO
Education
l PhD, Surgical Science, The University of Tokyo, Japan
l MS, Oral and Maxillofacial Surgery, Kaohsiung Medical University, Taiwan
l DDS, School of Dentistry, Kaohsiung Medical College, Taiwan
Current Position
l Chief, Liberty Lab of Tissue Engineering Takao, Kaohsiung, Taiwan
l Associate Professor, Division of Oral and Maxillofacial Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan
l Associate Professor, Institute of Precision Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan
l Researcher, Dept. of FUJISOFT Cartilage and Bone Regeneration, Tissue Engineering, The U of Tokyo
l Attending surgeon, Dept. of Oral and Maxillofacial Surgery, Hospital of Kaohsiung Medical University, Kaohsiung, Taiwan
Diploma
l Certificated Maxillofacial Surgeon of Taiwan
l Certificated Facial plastic and reconstructive surgeon of Taiwan
History in Profession
l July 1995, Admitted to Army Medical School for military training
l Oct 1995- June, 1997 Medical Officer ranked as Second Lieutenant at Infirmary of Infantry Division 146, the 8th Corps of Taiwanese Army
l Finished military service in Army
l July 1, 1997, Resident, Dept of Oral and Maxillofacial Surgery, Kaohsiung Medical University Hospital
l 2000-2001 Chief Resident, Division of Oral and Maxillofacial Surgery, Kaohsiung Medical University Hospital
l 2001-2002 Fellow and head, Div. of Oral and Maxillofacial Surgery, Kaohsiung Chang Kung Memorial Hospital
l Aug 1, 2002- Feb 28, 2006Attending Surgeon, Dept of Oral and Maxillofacial Surgery, Taichung China Medical University Hospital
l Sep 1, 2008 - Mar 31, 2010 Research Assistant of Global COE program
l Arp 1, 2010 - now Researcher, Fujisoft Dept (Lab) of Cartilage and Bone Regeneration, The University of Tokyo, Japan
Overseas clinical visit
l The U of Tokyo Hospital, Japan (2006-2010)
l Karl-Frazen Universität, Graz and Medizinische Universität Wien, Austria (2003)
l St Mary’s Hospital of Catholic University and Jelim Plastic Surgery Clinic, Seoul, Korea (2010, 2011, 2014)
- China Medical University in Shenyang, China, and the 9th People’s Hospital in Shanghai, China (2011)
2022年11月5日 星期六
Jaden Chun-yin LEE
DDS, National Yang-Ming University
Specialist, Oral and Maxillofacial Surgery in Taichung veterans general hospital
Specialist, Taiwanese Association of Oral and Maxillofacial surgeons
Specialist, Taiwan Academy of Osseointegration
Member, Academy of Osseointegration, USA
Specialist and director, Imperial dental care, Hsinchu City
李俊瑩醫師
學歷：
國立陽明大學牙醫學士
經歷：
台中榮民總醫院口腔醫學部 住院醫師，總醫師
台中榮總口腔顎面外科專科醫師
中華民國口腔顎面外科專科醫師
台灣植牙醫學會專科醫師
台灣植牙聯盟醫學會專科醫師
紐約哥倫比亞大學植牙教育專班
美國骨整合學會會員
現任：
新竹品御牙醫診所負責醫師
All-on-4及導航植牙訓練課程指導講師
New Techniques of Dynamic Guided Surgery in Complex Full Mouth Rehabilitation
Jaden Chun-yin LEE
Dynamic guided surgery has become an essential technique in the rehabilitation of severe atrophy of jaw bones. This time, I will introduce two updated techniques in navigation surgery. One is a fiducial-free technique, which is the so-called X-Mark technique. The other is the improvement of tracker fixation with EDX screws. Both techniques are imperative in All-on-4 and zygoma implant therapy.
2022年11月3日 星期四
Exhibitor
Exhibition 25, 000 NTD展覽廠商：25000元書商: 15000元不展覽廠商：15000元 (手冊內頁和本網站)請向黃麗玲小姐或柯政全醫師報名 ko.edward.kaseizen@gmail.com
Exhibition 25, 000 NTD
展覽廠商：25000元
書商: 15000元
不展覽廠商：15000元 (手冊內頁和本網站)
請向黃麗玲小姐或
柯政全醫師報名 ko.edward.kaseizen@gmail.com
國內匯款 Domestic
彰化銀行 009 博愛分行帳號 8244 51 290287 00
戶名 柯政全海外匯款 Overseas Participant 200 USD (20,000 Yen, 1000 RMB)
Name of Bank: Chang Hwa Bank
Branch Address: No.517, Bo’ai 1st Rd., Gushan Dist., Kaohsiung City 804-66, Taiwan
Swift Code: CCBCTWTP824
Account Number: 82445129028700
Name: Edward Cheng-Chuan KO
Branch Name of Bank: Boai Branch
2022年11月1日 星期二
Program
3rd Takao Forum of OMFS, 2022壬寅年
3rd Takao Forum of OMFS, 2022壬寅年
Official Language: English
Day 1 Nov18 第一工tē-it kang 十一月十八日 拜五pài-gō͘ | |||
DATE Nov 18 | TIME | SPEAKERS | TOPICS |
13:30 | 報到 Check-in | ||
13:50 | Organizing Chair: Edward Chengchuan KO 柯 政全 KMU President Professor Chun-Yuh YANG 高雄醫學大學校長楊俊毓教授 President TAOMS, Prof Elliot Shih-Jung CHENG 鄭 世榮理事長致詞 | Opening | |
14:05 ~ 15:35 | Moderators: Micheal YC CHEN, Han-Jen HSU 座長：陳 遠謙，許 瀚仁 | ||
Orthognathic Surgery 正顎手術 | 14:05 ~ 14:25 | Chihyu PENG Chang Shan Med UH, Taichung, TWN 中山醫學大學 彭 芷瑜🇹🇼 | Pitfall and Pearls of Vertical Ramus Osteotomy – 20-year Experience at CSMUH 下顎骨垂直直枝截骨術的陷阱與真珠 – 20年中山醫大經驗 |
14:25 ~ 14:45 | Chun-Ming CHEN Kaohsiung Med U, Takao, TWN 高雄醫學大學 陳 俊明🇹🇼 | Integrated Anterior Maxillary Subapical Osteotomy 綜合性前上顎根尖下截骨術 | |
14:45 ~ 15:05 | Ming-Chih Mark CHANG FaceMaker Clinic, Taipei, TWN 煥顏 張 明智🇹🇼 | Office-based Orthognathic Surgery 口外專科診所的正顎手術 | |
15:05 ~ 15:35 | National Singapore U, SNG 國立新加坡大學 黃 忠永 🇸🇬 | ||
Coffee Break 啉咖啡 ☕ (lim ka-pi) | |||
15:50 -17:10 | Moderators: Charles Kuan-Chou LIN, Chin-Wen LUO 座長：林 冠州、羅 金文 | ||
TMJ 顳顎關節 | 15:50-16:10 | Hsiu An HSU ShinChan Clinic, Taipei心湛 許 修銨🇹🇼 | TMJ Arthroscopy: Basic Techniques 顳顎關節鏡：基本技術 |
OMFS in Japan 日本口腔顎面外科 | 16:10 -16:30 | Kanchu TEI Hokkaido U, Sapporo, JPN 北海道大學 鄭 漢忠 🇯🇵 | Situations of the Oral and Maxillofacial Surgeons in Japan |
Oncology 腫瘤 | 16:30- 16:50 | Kazuyo KURIBAYASHI Hokkaido U, Sapporo, JPN 北海道大學 栗林 和代🇯🇵 | Postsurgical Swallowing Function in Patients with Oral Cancer 口腔癌患者術後吞嚥功能 |
16:50 ~ 17:10 | Jehn-Shyun HUANG Nat’l Cheng Kung U, Tainan, TWN 國立成功大學 黃 振勲🇹🇼 | Emerging Dilemma in the Treatment of Mandibular Metastasis 轉移至顎骨之惡性腫瘤之治療困境與對策 | |
New Technology in Oncology 新視野 | 17:10 ~ 18:00 | Moderators: Elliot Shih-Jung CHENG, Che-Wie WU 座長：鄭世榮、吳 哲維 | |
17:10 – 17:30 | Kazuyo IGAWA Okayama U, Okayama, JPN 岡山大學 井川 和代🇯🇵 | Current Status Boron Neutron Capture Therapy for Head and Neck Cancer 頭頸癌的硼中子俘獲治療法現狀 | |
17:30 – 18:00 | Tsung-Lin YANG Nat’l Taiwan U, Taipei, TWN 國立台灣大學耳鼻喉部 楊 宗霖🇹🇼 | Cell Therapy in Otorhinolaryngology and Head Neck 耳鼻喉科與頭頸部之細胞治療 | |
ta̍k-ke hip-siōng Group Photo 逐家 翕相 | |||
19:00 Speakers Night ShihChuan Restaurant, Old New Taiwanese Cuisine 老新臺菜 十全店 | |||
Day 2 Nov19第二工tē-jī kang 十一月十九日 拜六pài-la̍k | |||
DATE Nov 18 | TIME | SPEAKERS | TOPICS |
Material for Rhinoplasty | 8:30 ~ 8:50 | Tian Ee SEAH TES Clinic for Face and Jaw, SNG 謝 天毅🇸🇬 | Use of Polycaprolactone Materials in Rhinoplasty. （Video） |
MRONJ | 8:50 ~ 9:10 | Chi-Ho MOON, Yong-Deok KIM Pusan Natl U, Busan, KOR 國立釜山大學 金 容德🇰🇷 | Suppression of Osteoclastogenesis by Dermokine via Suppressing RANKL-Induced Signaling Pathways in Periodontitis (Video) |
09:10 ~ 09:50 | Moderators: Wen-Hui CHEN, Wei-Ting LIN 座長：陳 文惠、林 蔚庭 | ||
Imaging Guided 影像導引 | 09:10 ~ 09:30 | Hsin-Hui PENG Nat’l Taiwan U, Taipei, TWN 國立台灣大學 彭 馨慧🇹🇼 | Clinical Application of Head and Neck Ultrasound 頭頸部超音波影像的臨床應用 |
09:30 ~ 09:50 | Chieh-Yuan CHENG MacKay Memorial Hospital, Taipei, TWN 台北馬偕紀念醫院 鄭 介原🇹🇼 | What Weapons Are Available in the Face of Sialolithiasis? 處理唾液腺結石的可用武器 | |
09:50 - 10:00 | Coffee Break 啉咖啡 ☕ (lim ka-pi) | ||
10:00 ~ 11:10 | Moderators: Mario ESQUILLO, Sin PAI 座長：馬力歐 愛斯基洛、白 馨 | ||
Perspectives 展望 | 10:00 ~ 10:20 | Ken-Chung CHEN Nat’l Cheng Kung U, Tainan, TWN 國立成功大學 陳 畊仲🇹🇼 | Is Membrane Necessary in Bone Regeneration? 在骨引導再生中，再生膜是否必要？ |
10:20 ~ 10:40 | Wen-Liang LO Taipei Veteran General Hospital, Taipei, TWN 台北榮民總醫院 羅 文良🇹🇼 | Precision Medicine of Temporomandibular Disorders in the Era of Metaverse 在元宇宙時代的顳顎關節疾病之精準醫學治療 | |
10:40 ~ 11:10 | Anthony Shou-Yen KAO Taipei Veteran General Hospital, Taipei, TWN 台北榮民總醫院 高 壽延🇹🇼 | The Current Status of Medical Artificial Intelligence Development in Taipei Veteran General Hospital. 台北榮民總醫院人工智慧醫療發展現況 | |
11:10 ~ 12:20 | Moderators: Wen-Liang LO, Kazuyo IGAWA 座長： 羅 文良、井川 和代 | ||
Orthognathic Surgery 正顎手術 | 11:10 ~ 11:40 | Toshihiko TAKENOBU Osaka Dental U, Osaka, JPN 大阪齒科大學 竹信 俊彥🇯🇵 | “Paradigm Shift” in Orthognathic Surgery- Occlusion First to Face First典範轉移：從咬合優先到顏面優先 |
11:40 ~ V 12:10 | Michael Yuanchien CHEN China Med U, Taichung, TWN 台中中國醫藥大學 陳 遠謙🇹🇼 | Complications of OgS ～Troubles I’ve Met. 我所遇到的正顎手術併發症 | |
Piezo Technique Note 超音波骨刀 | 12:10 ~ 12:20 | Edward Chengchuan KO Kaohsiung Med U, Takao, TWN 高雄醫學大學 柯 政全🐯🇹🇼 | Medial Approach to Mandibular Condyle for Intraoral TMJ Gap Arthroplasty by using Piezo and Surgical Guide 使用超音波骨刀從下顎骨髁頭內側進行口內關節形成術 |
Luncheon (limited attendance: 60 seats) | |||
12:30 ~ 13:00 | 杏昌提供 Jaden Chun-Yi LEE李 俊瑩🇹🇼 單顆至多顆植體及顴骨植體導航之最新應用 New Techniques of Dynamic Guided Surgery in Complex Full Mouth Rehabilitation | ||
12: 20 -13:25 LUNCH 中晝頓tiong-tàu-tǹg | |||
Moderators: Jang-Jaer LEE, Kuan-Min HUANG 座長：李 正喆、黃冠閔 | |||
Reconstruction 重建 | 13:25 ~ 13:45 | Mario ESQUILLO 🇵🇭 Los Santos Med Center, Quezon, PHL 馬力歐 愛斯基洛🇵🇭 | Overcoming the Challenges in Dental Implant Rehabilitation of a Reconstructed Mandible with Fibular Flap 克服於腓骨皮瓣重建之下顎骨植牙時所遇到的挑戰 |
MRONJ | 13:45 ~ 14:05 | Ling-Ying WEI Nat’l Taiwan U, Taipei, TWN 國立台灣大學 魏 鈴穎🇹🇼 | Prognosis of Medication-Related Osteonecrosis of Jaw in Patients Using Antiresorptive Agent 使用抗骨鬆藥物病人的顎骨壞死MRONJ預後 |
14:05 14:20 | Edward Chengchuan KO Kaohsiung Med U, Takao, TWN 高雄醫學大學 柯 政全🐯🇹🇼 | Hypoxia aggravates cell death and poor fibronectin deposition of the human gingival fibroblasts treated with Alendronate. 缺氧會加重用福善美處理的人類牙齦纖維母細胞的細胞死亡和纖連蛋白沉積不良。 | |
14:20 ~ 15:50 | Moderators: Kuo-Yang TSAI, Chu-Chiang KAO 座長：蔡 國陽、高 主強 | ||
Oncology 腫瘤 | 14:20 ~ 14:40 | Hsifeng TU Nat’l YMCT Uni Hospital, Yilan, TWN 國立陽明交通大學 涂 曦丰🇹🇼 | The Application of Intraoperative CBCT in Oral and Maxillofacial Surgery 術中CBCT在口腔顎面外科中的應用 |
14:40 ~ 15:00 | Wei-Fang CHIANG ChiMei Medical Center, Liouying, TWN 柳營奇美醫學中心 蔣 維凡🇹🇼 | Survival analysis of recurrent and metastatic oral squamous cell carcinoma: does surgical salvage affect the outcome? 復發性和轉移性口腔鱗狀細胞癌的生存分析：手術搶救會影響結果嗎？ | |
15:00 ~ 15:30 | Elliot Shih-Jung CHENG Nat’l Taiwan U, Taipei, TWN 國立台灣大學 鄭 世榮🇹🇼 | Surgical Consideration for Parotid Gland Tumors 耳下腺腫瘤的外科考量 | |
15:30 ~ 15:50 | Yuwei CHIU Chang Shan Med UH, Taichung, TWN 中山醫學大學 邱 昱瑋🇹🇼 | Surgery Management of Late-Stage Oral Cancer 晚期口腔癌的手術治療 | |
15:50 - 16:00 Music: Dr William ChunChih CHEN and KMU Singers 陳俊志醫師暨高醫聲樂社 | |||
16:00- 16:20 Coffee Break 啉咖啡 ☕ (lim ka-pi) 👁看展覽（khòaⁿ tián-lám） | |||
Day 2 Nov19第二工tē-jī kang 十一月十九日 拜六pài-la̍k | |||
DATE Nov 19 | TIME | SPEAKERS | TOPICS |
Moderators: Toshihiko TAKENOBU, Edward Chengchuan KO 座長：竹信 俊彦、柯 政全 | |||
Reconstruction 重建 | 16:20 ~ 16:40 | Richard Yuxiong SU Hong Kong U, HKG 香港大學 蘇 宇雄🇭🇰 | Functional Jaw Reconstruction after Ablative Surgery: the New Trend 切除手術後功能性顎骨重建：新趨勢 (video) |
16:40 ~ 17:10 | Cheng-Hsien WU Taipei Veteran General Hospital, Taipie, TWN 台北榮民總醫院 吳 政憲🇹🇼 | Computer-aided Cranioorbital Surgery 電腦輔助顱眼眶手術 | |
17:10 ~ 18:00 | Tetsu Takahashi Tohoku U, Sensai, JPN 東北大學 高橋 哲🇯🇵 | Use of Octacalcium Phosphate and Collagen Composite (Bonarc®) in Oral and Maxillofacial Surgery 磷酸八鈣和膠原蛋白複合物 (Bonarc®) 在口腔顎面外科中的應用 Periosteal Expansion 骨膜擴張術 | |
18:00 | Group Photo 逐家ta̍k-ke 翕相hip-siōng 写真 | ||
國賓20F 晚宴 | 19:00 | Gala Dinner Top of Ambassador | |
Day 3 Nov20 第三工tē-saⁿ kang 十一月二十日 禮拜lé-pài | |||
DATE Nov 20 | TIME | SPEAKERS | TOPICS |
Orthognathic Surgery 正顎手術 | 8:25 ~ 8:50 | Mike Yiu Yan LEUNG Hong Kong U, HKG 香港大學 梁 耀殷🇭🇰 | Prevention and Management of Common Complications of Sagittal Split Ramus Osteotomy (V)矢狀劈開截骨術常見併發症的之預防與處理 |
Moderators: Hsi-Feng TU, Wei-Chai SU 座長：涂 曦丰、蘇 偉嘉 | |||
Technique Note | 8:50 ~ 9:05 | Pei-Jung CHEN Kaohsiung Med U, Takao, TWN 高雄醫學大學 陳 珮蓉🇹🇼 | A Novel Material to Secure Artificial Dermis - Technique Note for Putty Type Silicone Used in Transbuccal Fixation Procedure |
Orthognathic Surgery 正顎手術 | 9:05 ~ 9:25 | Henry Hung-Ying LIN Nat’l Taiwan U, Taipei, TWN 國立台灣大學 林 鴻穎🇹🇼 | Computer Aided Surgical Simulation in Orthognathic Surgery- from 2D to 3D Surgical Planning 正顎手術中的電腦輔助手術模擬——從 2D 到 3D 手術規劃 |
Tumor腫瘤 | 9:25 ~ 9:45 | Shiao-Pieng LEE Tri-Service General Hospital, Taipei, TWN 三軍總醫院 李 曉屏🇹🇼 | Clinical Practice Guidelines and Modern Management Approaches for Craniofacial Fibrous Dysplasia 顱顏面纖維發育不良的臨床指南和當代處置路徑 |
Moderators: Huan-Chang LIN, Henry Hung-Ying LIN 座長：林 煥章、林 鴻穎 | |||
Veterinary Medicine 獸醫 | 9:45 ~ 10:05 | Cheng-Shu CHUNG Nat’l Pingtung University of Science and Technology 屏東科技大學 鍾 承澍🇹🇼 | Maxillofacial Surgery in Veterinary Medicine 獸醫學中的口腔顎面外科 |
Tumor腫瘤 | 10:05 ~ 10:25 | Chisheng CHENG Taichung Veteran General Hospital, Taichung, TWN 台中榮民總醫院 程 稚盛🇹🇼 | Anatomicopathological Consideration of Surgical Approaches in the Oral Cavity Cancer 口腔癌手術路徑的解剖病理學考慮 |
Trauma 外傷 | 10:25 ~ 10:45 | Takahiro KANNO Shimane U, Izumo, JPN 島根大學 管野 貴浩 | Trends of Surgical Approaches for Open Reduction and Internal Fixation of Mandibular Condyle Fracture 下顎髁頭骨折觀血性復位內固定手術路徑趨勢 |
10:45 ~ 11:05 | Takahiro KANNO Shimane U, Izumo, JPN 島根大學 管野 貴浩🇯🇵 | Up-to-date Computer-Assisted Orbital Trauma Reconstruction 最新電腦輔助眼眶骨創傷重建 | |
11:05 ~ 11:20 | Coffee Break 咖啡歇睏 | ||
11:20 ~ 12:00 | Moderators: Michael Yuanchien CHEN, Edward Chengchuan KO 座長：陳 遠謙、柯 政全 | ||
Orthognathic Surgery 正顎手術 | 11:20~ 11:40 | Je Uk PARK Medical College of the Catholic University of Korea, Seoul, KOR 韓國天主教大學 朴 載億🇰🇷 | Basic Principles of Orthognathic Surgery 正顎手術基本原則 |
11:40~ 12:00 | Je Uk PARK Medical College of the Catholic University of Korea, Seoul, KOR 韓國天主教大學 朴 載億🇰🇷 | Surgery First Approach Orthognathic Surgery 手術先行的正顎手術進策 | |
Closing | |||