Chi-Ho Moon*, Yong-Deok Kim*
Dept. of Oral and Maxillofacial Surgery, School of Dentistry,
Pusan National University
Introduction:
In alveolar bone, bone resorption and bone formation are balanced by the regulation of various hormones and cytokines, so that new bone replaces old bone and stabilizes the volume of alveolar bone. This process is called bone remodeling.
Dermokine is a predominantly secreted glycoprotein localized in epithelial tissues and is differentially regulated in inflammatory conditions. The association of dermokine in various organs, such as pancreatic cancer and colorectal cancer, has been reported, ranging from an increase in inflammatory skin disease to inhibition of skin wound healing. However, there are few studies on dermokine in periodontitis.
The purpose of this study was to investigate the relationship between periodontitis and dermokine
Materials and Methods:
The expression of dermokine in the public database is confirmed in periodontitis patients. The expression of dermokine in human gingival fibroblasts was confirmed by treatment with LPS. The expression of dermokine was confirmed by inducing gingivitis in 6-week-old male mice. The cytotoxicity of dermokine was confirmed in Mouse Bone Marrow-Derived Macrophages. After dermokine treatment, check the formation of osteoclasts. After dermokine treatment, the expression of five Transcription Factors (TRAP, cathepsin K, DC-STAMP, NFATc1, c-Fos, ERK, JNK, p38) is confirmed.
Results:
Dermkine acts as a negative regulator of osteoclast differentiation in the periodontitis environment and mediates the MAPK pathway.
Keywords:
Dermokine, Osteoclastogenesis, RANKL
